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Treatment of Sleep Disorders: Jump Start of Respiration Without Inducing Arousal or Wake
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID: 1533
Sleep apnoea is a sleep disorder characterized by repetitive cessation or decreased amplitude of breathing lasting 10s or more, that may occur up to hundreds of times per...
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Introduction/Background

Sleep apnoea is a sleep disorder characterized by repetitive cessation or decreased amplitude of breathing lasting 10s or more, that may occur up to hundreds of times per night. The cessations of breath lead to oxyhemoglobin desaturation that often leads to awakening. The prevalence of the disorder is 4% and 2% in middle-aged men and women, respectively. Additionally, 7% of the population suffer from a mild sleep apnoea. There has been limited success in treating apnoea with pharmacological and surgical methods, and the standard treatment for apnoea remains a device consisting of a pump and nasal mask that provide continuous positive airway pressure. The major disadvantage of this device is the relatively low compliance (12% of users abandon therapy after 1 night, and only 46% use this device on a regular daily basis).

Aims/Hypothesis

Thus, apnoea remains an often untreated disorder. The present technology triggers an odour at the onset of sleep apnoea, thus jump-starting the respiratory pattern without inducing arousal or wake.

Results

Odours have been long suggested as a possible treatment for sleep apnoea. The novel finding in this technology is that odours modify respiration during sleep, where they decrease inhalation and increase exhalation volume for several breaths after odour onset. An odorant stimulus is provided such that it is not a puff of air but rather a block of odorant embedded within a constant airflow. Therefore, this method may serve as a platform to treat sleep apnoea.

Conclusion

A method to treat sleep apnoea without causing arousal or wake.

Relevance/Opportunity

Please enquire quoting reference 1533 regarding licensing or codevelopment partnerships.
FEATURED
Last Updated May 2015
Technology Type THERAPEUTIC
Phase of Development PRECLINICAL
CORPORATION