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Yeda R&D Co. Ltd
Abstract ID: 1343
Breast cancer is the second most commonly diagnosed cancer among U.S. women, with a 13% incidence. The use of screening tests for early detection of breast cancer and...
Breast cancer is the second most commonly diagnosed cancer among U.S. women, with a 13% incidence. The use of screening tests for early detection of breast cancer and other cancers provides better opportunities for patients to survive these cancers, with fewer side effects. Oestrogen receptor (ER) is a well-established marker of breast cancer, and therefore the capacity to map this receptor may indicate high risk for cancer development. Current clinical methods that measure ER are subjective and semi-quantitative, or suffer from low target to non-target tissue image contrast. Hence, an accurate, standardized in vivo method to determine ER level would highly improve patient's care.
There is a need for a non-invasive method to diagnose breast cancer.
Cancers such as breast and prostate cancer most frequently express the steroid receptors of their origin and can accumulate molecules that have high binding affinities for the receptors, namely, receptor ligands. In the outlined technology, new MRI sensitive ligands that bind specifically to the oestrogen receptor were synthesized, in order to identify the presence of the receptors by non-invasive MRI methods. These probes can map the oestrogen receptor in vivo using contrast enhanced MRI.
The present invention allows for the identification of ER by specific MRI contrast agents.
Please enquire regarding licensing or codevelopment partnerships quoting reference no. 1343.
Last Updated May 2015