Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/detail.php on line 234

Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 82

Warning: array_push() expects parameter 1 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 85
Pharmalicensing | Life Science's Global Technology Marketplace
Save this technology
close
Save to Existing Project
Save to a New Project
Autonomous Cell-State Sensing Device: Identification of Aberrant Versus Normal Growth of Cells
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID: 1386
The state of a cell can be diagnosed by monitoring the activity patterns of its various pathways. In most cases it is essential to monitor the activity of...
Contact Galit Mazooz, ph.d.
Participants
You
Email me a copy of this message
Introduction/Background

The state of a cell can be diagnosed by monitoring the activity patterns of its various pathways. In most cases it is essential to monitor the activity of several genes in order to accurately determine a cell state. Ex vivo techniques allow identification of cell states not by the cell itself, but rather by external observation, and schemes for in vitro autonomous diagnosis are yet to be implemented in living cells.

Aims/Hypothesis

Therefore, a general synthetic approach for diagnosing natural cell states is needed.

Research

In the outlined technology the state of a cell is diagnosed internally by the cell itself, using a simple genetic system that measures the integrated activity of a few pre-defined genes. The state of a cell is defined by its phenotypic and genotypic properties. It can be diagnosed by the unique activity pattern associated with that state. The current technology offers an autonomous cell-state determination in yeast, by defining a minimal set of genes, whose concurrent activity pattern provides precise identification of the state of interest. The integrated readout is obtained by coupling the activity of the input genes. The products of these two genes are used to drive the expression of a reporter or effector gene.

Conclusion

We have developed a simple system for diagnosing the state of a cell.

Relevance/Opportunity

Identification of aberrant versus normal growth of cells. Please enquire regarding licensing or codevelopment partnerships.
GO PREMIUM TO GET PATENT INFORMATION
FEATURED
Last Updated May 2015
Technology Type DIAGNOSTIC
Phase of Development CLINICAL TRIALS
CORPORATION