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On-Chip Synthesis of Biomolecules with High Efficiency, Minimal Non-Specific Activity, and a Wide Dynamic Range
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID: 1369
Biochip technology, which is used today for measuring only passive probe-target interactions (such as measuring the abundance of specific biomolecules), can be extended to include complex and cascaded...
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Introduction/Background

Biochip technology, which is used today for measuring only passive probe-target interactions (such as measuring the abundance of specific biomolecules), can be extended to include complex and cascaded activities on the chip. The present immobilization approaches (based on UV photography) have been essentially limited to short single stranded DNA probes and have not been developed for entire genes or other biochemical functions. Furthermore, most biochips are assembled in a multi-step process that requires expertise in surface chemistry in order to obtain reproducibility and robustness. As a result, light-directed immobilization of molecules on biochips is not widespread and is not easily accessible for research and technology development.

Aims/Hypothesis

There is thus a need for the development of a method for on-chip protein biosynthesis.

Research

The present invention enables, in a simple manner, to immobilize different biomolecules anywhere on the chip to submicron resolution through selective exposure of the monolayer to UV light. This lab-on-a-chip technology (i.e. a technology that enables to perform laboratory operations on a small scale) is based on a newly synthesized molecule termed daisy that combines three parts all-in-one: a tail and head connected by a backbone. Selective exposure of daisy monolayer to UV light through a mask (photolithography) reveals the surface for chemical binding of a variety of biomolecules. Using this technology it is possible to immobilize different biomolecules anywhere on the chip to submicron resolution. By immobilizing whole genes, thus enabling cell-free biosynthesis of proteins, daisy technology takes the lab-on-a-chip concept to the next level. Daisy biochip technology holds a promise in proteomics, diagnostics and therapeutics.

Conclusion

We have developed a simple, single-step biochip platform for synthesis of biomolecules.

Relevance/Opportunity

Please enquire regarding licensing or codevelopment partnerships quoting reference no. 1369.

FEATURED
Last Updated May 2015
Technology Type PLATFORM
Phase of Development CLINICAL TRIALS
CORPORATION