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Immune Therapy for Treating Mental Disorders
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID: 1517
Psychological disorders (eg, schizophrenia, depression, etc.) are among the most prevalent diseases of humankind. These disorders affect approximately 16% of the U.S. population aged 18 and older in...
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Introduction/Background
Psychological disorders (eg, schizophrenia, depression, etc.) are among the most prevalent diseases of humankind. These disorders affect approximately 16% of the U.S. population aged 18 and older in a given year, and when less severe conditions are considered as well (eg, obsessive-compulsive behaviour), the percentage is even higher (about 26%). Hitherto, no disease-modifying therapy has been available for any of these diseases, with the conventional treatments being psychotherapy and non-therapeutic medications whose use is complicated by side effects and limitations in the amount of time they can be administered.

Aims/Hypothesis
The market for an effective disease-modifying therapy is, therefore, potentially huge.

Results
The basis of the therapeutic approach proposed in this technology is the groundbreaking discovery that peripheral immune cells play a key role in adult brain plasticity and that immune deficiency or malfunction can impair brain plasticity. Furthermore, it was found that the immunization of mice suffering from one of the above psychological disorders alleviated their symptoms. The recognition that the systemic immune system is a factor in containing mental stress offers new directions for the development of a therapy for stress-induced pathologies such as PTSD and depression. This T cell-based immunization increases the body's physiological ability to cope with stress.

Conclusion
We have developed a unique immune-based therapy to treat psychological disorders. The present technology offers the use of therapeutic vaccinations to boost the body's own repair mechanisms.

Relevance/Opportunity
Treatment of acute and chronic psychological disorders such as schizophrenia, depression, post-traumatic stress disorder (PTSD), and attention deficit disorder. Preventative vaccination for some of the above disorders. Please enquire quoting reference no. 1517 regarding licensing or codevelopment partnerships.
FEATURED
Last Updated May 2015
Technology Type THERAPEUTIC
Phase of Development PRECLINICAL
CORPORATION

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