Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/detail.php on line 234

Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 82

Warning: array_push() expects parameter 1 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 85
Pharmalicensing | Life Science's Global Technology Marketplace
Save this technology
close
Save to Existing Project
Save to a New Project
Liposomes Highly Efficient Biocompatible Based Lubricant Material
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID: 1569
Liposomes are vesicles formed by natural lipids commonly named phospholipids. Phospholipids contain the phosphocholine head group which has great impact on their characteristics. In...
Contact
Participants
You
Email me a copy of this message
Introduction/Background

Liposomes are vesicles formed by natural lipids commonly named phospholipids. Phospholipids contain the phosphocholine head group which has great impact on their characteristics.

Aims/Hypothesis

In general the use of natural lipids provides biocompatibility; liposomes are frequently used as drug delivery agents, and we now propose to use them for bio-lubrication purposes.

Results

Our phosphatidylcholine liposomes, which are in their more rigid gel phase, form close-packed boundary layers in a hydrated environment. This leads to a striking reduction of the friction coefficient at high pressures because the uniform close-packed arrangement of these liposomes creates a particularly robust layer. These characteristics make these liposomes excellent candidates for use as boundary lubricant materials.

Our phosphatidylcholine liposomes spontaneously adsorb and self-assemble onto a solid surface in aqueous solution to form a robust boundary layer which provides extremely efficient lubrication at the interfaces. The lubrication occurs under pressures of up to 100 atmospheres or more. These characteristics are preserved up to the gel-to-liquid-crystalline phase transition temperature (Tm= 53?C for the HSPC liposomes for example). The lipids head groups which are highly hydrated and exposed at the outer liposome surfaces provide these remarkable properties by virtue of the hydration lubrication mechanism.

Conclusion

Bio-lubricant materials for medical applications such as reduction of skin soreness from rubbing and suppression of plaque formation, and in biomedical devices including catheters, cosmetic applications such as use in conditioners and shampoos and friction reducers in synovial joints where osteoarthritis-related problems arise.

Relevance/Opportunity

Please enquire quoting reference no. 1569 regarding licensing or codevelopment partnerships.
FEATURED
Last Updated May 2015
Technology Type PLATFORM
Phase of Development PRECLINICAL
CORPORATION