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Heat and Light-activated Carbon Monoxide Releasing Molecules as Bactericidal and Anti-inflammatory Agents
University of York United Kingdom flag United Kingdom
Abstract ID:
We have produced a panel of compounds that release carbon monoxide at specific temperature thresholds or levels of light exposure, providing a controllable bactericidal and anti-inflammatory mechanism....
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MECHANISM OF ACTION
CO-releasing molecules (CO-RMs) activated by heat or light to release their payloads. Exploring usage in the form of creams and gels for topical application.
We have produced a panel of compounds that release carbon monoxide at specific temperature thresholds or levels of light exposure, providing a controllable bactericidal and anti-inflammatory mechanism. Possible applications include burns, ulcers, skin infections and sexually transmitted bacterial infections

Carbon monoxide (CO) is a well-documented respiratory poison, being dangerous to humans at concentrations of greater than 100 parts per million. However, CO is produced in small quantities endogenously, via catabolism of heme, eliciting an anti-inflammatory effect, along with other exploitable therapeutic properties.

Notably, low concentrations of CO are bactericidal in some clinically significant pathogenic species. CO is, therefore, one of the simplest drug compounds ever to have been identified. A key challenge in making use of CO therapeutically is that it is dangerous and difficult to apply in its gaseous form.

We have developed a library of CO-releasing molecules (CO-RMs) that are activated by heat or light to release their payload. In in vitro tests, the CO-RMs are well tolerated by mammalian cells and upon activation, show a potent killing-effect on pathogenic bacteria such as N. gonorrhoeae and S. aureus. We wish to explore the use of CO-RMs with carrier agents, in the form of creams and gels, for topical application to sites of infection and injury.

We are exploring the use of CO-RMs with carrier agents, in the form of creams and gels, for topical application to sites of infection and injury.
Type of Business Relationship Sought
We are seeking commercial partners, especially those with established wound-healing models, to collaborate in further research and development and to lead exploitation of the technology.
FEATURED
Last Updated Sep 2014
Technology Type PLATFORM
Phase of Development EARLY STAGE
UNIVERSITY