Compositions and methods for Improved Organ Transplant Outcomes: tissue protection during transport and storage
Application: Protection against injury to organs or tissues during pre-transplant storage and transport
In 2009 over seventy thousand organ transplants were performed and the number is growing each year. Approximately 60% of those transplants involve kidney transplants. There is a growing list of people in need of organ transplants and research involving better methods is needed to preserve available organs. Current research has demonstrated that the increased oxidant and free radical production contributes to the organ damage prior to and following organ transplantation. Cold preservation and ischemia contribute to the deterioration of the organs and tissues during the period of organ isolation for testing and while a suitable recipient is being located. This damage limits the number of organs available for transplantation and can lead to limited function of the transplanted organ. The present invention provides a composition for the cold storage of organs which reduces oxidation effects of cold storage and reduces the oxidative damage to an organ or tissue. The composition comprises a biochemical substrate that is targeted to the mitochondria and functions as an electron transporter to stabilize various reactive oxygen species that are one source of tissue and organ damage. The composition is the property of a third party with which the University is currently collaborating. The methods of use for this are the proprietary information of the University.
The composition includes a mitochondrial specific antioxidant moiety related to the lipophilic electron transporter called coenzyme Q10 that is covalently attached to a triphenylphosphonium cation.
This invention could make available much greater numbers of human organs for transplantation, reduce the number of discarded human organs prior to transplantation and improve the outcomes for organs that have been transplanted.
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