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MRI Imaging of Oxidative Radicals for Monitoring Drug Activity
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID:
An online method for functional monitoring and follow-up of treatment progression of a therapeutic modality based on Blood Oxygenation Level-Dependent (BOLD) magnetic resonance imaging (MRI). The therapeutic modality is applied to a disease or disorder......
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An online method for functional monitoring and follow-up of treatment progression of a therapeutic modality based on Blood Oxygenation Level-Dependent (BOLD) magnetic resonance imaging (MRI). The therapeutic modality is applied to a disease or disorder treatable by local embolization, meaning by therapeutic introduction of a substance into a blood vessel in order to occlude it, such as some malignant and non-malignant diseases, or by recanalization, meaning a treatment leading to photodynamic reopening of previously occluded blood vessels like in cardiovascular disorders. The treatment involves a sensitizer drug which accumulates in the tissue of interest, and upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption or depletion. The change in the oxygen level result in changes in BOLD-MRI contrast. This technique can be used to in vivo, real time evaluation of response to treatment, during the sensitized treatment. The method is preferably applied to photodynamic therapy (PDT).


Applications






    • Online imaging of a diseased region within a patient's body for functional clinical guidance prior to a therapeutic treatment.





    • An interactive use of the information obtained by the online BOLD-MRI method for accurate delivery of irradiation to the target region of interest, consequently, this data can be used for monitoring and follow-up of treatment progression.





    • Can be performed intra-operatively for real-time assessment of the response of the treated region to the treatment.





Advantages






    • Imaging of the sensitized treatment zone.





    • Higher treatment accuracy and safety.





    • Decreases unwanted damage to neighboring non-diseased tissues.





    • A sensitive, inexpensive and non-invasive tool for monitoring treatment progression.





Technology's Essence


In this method a BOLD weighted MR-image of the target region of interest within the patient's body is generated at time t0. Then a sensitizer is administrated to the patient and the target region of interest within the patient's body is irradiated with the appropriate sensitizing radiation while the patient is placed in the magnetic field of an MRI spectrometer and is subjected to continuous MR imaging. Next a sole or a plurality of T2* weighted sequential BOLD MR images during and/or after irradiation are generated (time t). The data of time t0 and time t are being processed while generating a color-coded difference or ratio map on a pixel by pixel basis. This map is superimposed on the map generated at time t0 to obtain a composite image.


Licensing Status

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FEATURED
Last Updated May 2016
Technology Type MEDICAL DEVICE
Phase of Development EARLY STAGE
CORPORATION