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Induction Peptide Expression in the Nervous System
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID:
An effective method for introducing peptides into the brain.Administration of synthetic or purified peptides directly into the brain ventricles is a method commonly used by neuroscientists for exploring physiological and behavioral functions of gene......
Contact Galit Mazooz, ph.d.
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An effective method for introducing peptides into the brain.


Administration of synthetic or purified peptides directly into the brain ventricles is a method commonly used by neuroscientists for exploring physiological and behavioral functions of gene products. Intra-ventricle administration is controlled by the blood–brain barrier, which limits its effectiveness, and currently available methods for the delivery of peptides or pharmacological agents into the cerebrospinal fluid (CSF) in the brain present researchers with limitations, concerning both the natural properties of the delivered substance (solubility, stability, synthesis, purifications, etc) and the experimental needs (prolonged and/or repeated administration, inducible delivery, minimal handling of the experimental animals, etc). The current technology utilizes a genetic approach for the specific delivery of secreted peptides or proteins into the CSF.


Applications






    • Administration of synthetic or purified peptides directly into the brain





    • Adaptable research tool for intracerebroventricular delivery





Advantages








    • Reliable and effective








    • The system is active and over-expresses the gene-of-interest product only at the choroid plexus cells








    • Provides reversible and inducible delivery of peptides or proteins into the CSF








    • This flexible system can easily be adapted for various methods such as chronic exposure, inducible expression, and minimal handling of animals, as well as alleviating the need for complex synthesis and purification protocols and the use of expensive micropumps






Technology's Essence


The choroid plexus is a blood–CSF barrier, composed of epithelial cells, that plays a critical role in the mechanism regulating the exchange of molecules between the brain’s internal milieu and the periphery. Neuromodulators directed to CSF can modify and adapt a variety of behavioral, neuroendocrine, and immunologic processes. The proposed technology is a lentiviral-based system which uses a choroid plexus specific promoter. The functionality of this system was demonstrated by using the over-expression of the two established neuropeptides. This technology may prove as a powerful tool for addressing research questions involving acute or chronic effects of gene products within the CNS.


Licensing Status

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FEATURED
Last Updated May 2016
Technology Type MECHANISM
Phase of Development EARLY STAGE
CORPORATION