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Targeting CD151 for Anti-Inflammatory Treatment
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID:
Down-regulation of CD151 as a means for treating inflammation.The surveillance of the body for foreign antigens is a critical function of the immune system.  Accordingly, B and T lymphocytes continually patrol the body for foreign antigens by......
Contact Galit Mazooz, ph.d.
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Down-regulation of CD151 as a means for treating inflammation.


The surveillance of the body for foreign antigens is a critical function of the immune system.  Accordingly, B and T lymphocytes continually patrol the body for foreign antigens by circulating from the blood, through tissues, into lymph nodes, and back to the blood.  The continuous recirculation of lymphocytes and their movement from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the pathogenesis of inflammatory diseases, autoimmune diseases, and the development and progression of allergic responses. The current invention targets the activity or expression of CD151, a molecule role involved in T cell migration, for treating inflammation.


Applications






    • Treatment of inflammation.





    • Treatment of other conditions which involve an inflammatory response (e.g. autoimmune diseases, allergic diseases, graft rejection diseases).





Advantages






    • Treatment of several conditions with the same compound.





    • A number of agents can be used to down-regulate the activity or expression of CD151 in a lymphocyte (e.g. RNA silencing agents, enzymes that cleave the polypeptide etc.)





Technology's Essence


In the present invention it has been uncovered that CD151 expression in T cells plays a key role in T cell migration and homing to the lymph nodes. The impaired homing of T lymphocytes to the peripheral lymph nodes results in attenuated progression of both asthma and adjuvant arthritis.  Thus, a blocking agent for the activity or expression of CD151 can exert global suppressive effects on T-cell trafficking and differentiation within peripheral lymph nodes, and may be clinically beneficial as an anti-inflammatory agent.


Licensing Status

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FEATURED
Last Updated May 2016
Technology Type THERAPEUTIC
Phase of Development EARLY STAGE
CORPORATION