Down-regulation of CD151 as a means for treating inflammation.
The surveillance of the body for foreign antigens is a critical function of the immune system. Accordingly, B and T lymphocytes continually patrol the body for foreign antigens by circulating from the blood, through tissues, into lymph nodes, and back to the blood. The continuous recirculation of lymphocytes and their movement from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the pathogenesis of inflammatory diseases, autoimmune diseases, and the development and progression of allergic responses. The current invention targets the activity or expression of CD151, a molecule role involved in T cell migration, for treating inflammation.
In the present invention it has been uncovered that CD151 expression in T cells plays a key role in T cell migration and homing to the lymph nodes. The impaired homing of T lymphocytes to the peripheral lymph nodes results in attenuated progression of both asthma and adjuvant arthritis. Thus, a blocking agent for the activity or expression of CD151 can exert global suppressive effects on T-cell trafficking and differentiation within peripheral lymph nodes, and may be clinically beneficial as an anti-inflammatory agent.