A wiki-based resource for sharing structural information of biological macromolecules. The information gleaned from structural biology studies is critical for understanding biological processes, and can facilitate drug discovery and design. A wealth of protein structures has been solved in recent years; however, three-dimensional structures are often hard to comprehend, making them less accessible to non-structural biologists. There is therefore an unmet need for a common resource that would make three-dimensional structures easier to understand, permit linking of function to structure, and at the same time simplify the sharing of structural information. The outlined technology is a web-based collaborative encyclopedia that displays protein structures and other bio- macromolecules in an interactive format.
Proteopedia is a wiki-based web-resource that has been designed to address what is missing from structural biology: a mechanism for presenting three-dimensional structures in an intuitive, easier to understand, a linking of function to interactive three- dimensional structure visualization, and a simplified sharing of structural and functional knowledge (a wiki is a resource or website where users can edit the pages in the website using simple text-editing tools). This resource is a tool for all scientists who need to utilize three-dimensional structural information in their research, as well as for educators requiring a medium for compelling presentation of structure-function relationships. http://www.proteopedia.org