An endoscopic photodynamic therapy system for tissue ablation by illumination of a photosensitizer drug in a target tissue. Ablation is defined as removal or excision of a body part or tissue or its function and can be carried out either surgically, by administration of hormones or drugs, by heating, by freezing or by radiofrequency. Photodynamic therapy (PDT) is a relatively new treatment modality best known for its applications in the therapy of cancer and macular degeneration. PDT can be defined as a highly controlled, minimally-invasive, local treatment. The system is directed toward a novel technological platform designed for optimal delivery of minimally invasive internal treatments by photodynamic means under controlled real-time imaging. It provides a method for focused tissue ablation in a target tissue of an individual while using the endoscopic imaging photodynamic therapy system. This system may be used in various medical applications where tissue ablation is required and photodynamic therapy may be applied, in particular, in the treatment of extra uterine pregnancy (EUP).
The EIPS is being applied for focused tissue ablation by illumination of a photosensitizer drug in a target tissue. PDT involves two non-toxic components that are combined at the treatment site to induce cellular and tissue damage in an oxygen-dependent manner: a nontoxic photosensitizer drug, administered systemically or locally and non-hazardous light of a matched wavelength that is delivered locally to the treatment site via optic fibers in a highly controlled and minimally-invasive manner. The photosensitization of the drug elicits the transfer of energy or an electron to molecular oxygen resulting in instant local generation of cytotoxic reactive oxygen species (ROS). The short half-life of ROS restricts diffusion distance to