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Gynecological Endosopic Photodynamic Therapy (GEPT)
Yeda R&D Co. Ltd Israel flag Israel
Abstract ID:
An endoscopic photodynamic therapy system for tissue ablation by illumination of a photosensitizer drug in a target tissue....
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An endoscopic photodynamic therapy system for tissue ablation by illumination of a photosensitizer drug in a target tissue. Ablation is defined as removal or excision of a body part or tissue or its function and can be carried out either surgically, by administration of hormones or drugs, by heating, by freezing or by radiofrequency. Photodynamic therapy (PDT) is a relatively new treatment modality best known for its applications in the therapy of cancer and macular degeneration. PDT can be defined as a highly controlled, minimally-invasive, local treatment. The system is directed toward a novel technological platform designed for optimal delivery of minimally invasive internal treatments by photodynamic means under controlled real-time imaging. It provides a method for focused tissue ablation in a target tissue of an individual while using the endoscopic imaging photodynamic therapy system. This system may be used in various medical applications where tissue ablation is required and photodynamic therapy may be applied, in particular, in the treatment of extra uterine pregnancy (EUP).


Applications






    • Trans-vaginal focused tissue ablation, particularly for ablation of the fetoplacental





    • Unit in ectopic location such as for extra uterine pregnancy (EUP) and other disorders.





    • Other medical applications where PDT may be applied for treatment: malignant and pre-malignant lesions, cardiology and other cardiovascular diseases, gastrointestinal tract lesions, respiratory system diseases, urinary tract diseases, musculoskeletal diseases, head and neck or neuronal and brain treatments.





Advantages






    • Highly controlled with accurate approach to the target tissue.





    • Local treatment, no general anesthesia.





    • Minimally-invasive.





    • Low energy lasers are commonly used.





    • Reduced complication rate.





    • Reduced recovery period.





Technology's Essence


The EIPS is being applied for focused tissue ablation by illumination of a photosensitizer drug in a target tissue. PDT involves two non-toxic components that are combined at the treatment site to induce cellular and tissue damage in an oxygen-dependent manner: a nontoxic photosensitizer drug, administered systemically or locally and non-hazardous light of a matched wavelength that is delivered locally to the treatment site via optic fibers in a highly controlled and minimally-invasive manner. The photosensitization of the drug elicits the transfer of energy or an electron to molecular oxygen resulting in instant local generation of cytotoxic reactive oxygen species (ROS). The short half-life of ROS restricts diffusion distance to

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FEATURED
Last Updated May 2016
Technology Type THERAPEUTIC
Phase of Development EARLY STAGE
CORPORATION