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Anti-Cancer Agent(AG60), Anti-Hepatitis, Anti-Fibrotic Agent, Anti-BPH Agent, Anti-Hypertensive & Cholesterol Lowering Agent, Anti-Cataract Agent_Medvill
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Anti-Atopic Dermatitis Cosmetics, Anti-Acne Cosmetics, Anti-Oxidants Vitaplus
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Products in Company Pipeline


 


 


 


 


 






 


Product


 






 


Description


 






 


Anti-cancer agent


 


 


 


(AG60) --- chemicals


 


 


 


 


 






 


•      Patent registration:  Korea and US


 


 


 


•       Pre-clinical studies approval; KFDA(Korean Food and Drug Administration (IND)


 


 


 


- Mode of Action:


 


 


 


•        Inhibition of tumor cell proliferation


 


 


 


•        Suppression of transcription factors (NF-kB and AP-1)


 


 


 


•        Anti-angiogenesis


 


 


 


•        Induction of apoptosis


 






 


Anti-hepatitis, anti-fibrotic agent - plant extract


 


 


 


 


 






 


- Patent registered in Korea


 


 


 


- Patents are pending in China and Japan


 


 


 


  China is a big market (60% of population is infected with hepatitis B virus)


 


 


 


- Efficacy:


 


 


 


•       Inhibition of liver fibrosis


 


 


 


•       Anti-viral activities against Hepatitis B virus and Hepatitis C virus (in a several human cases)


 


 


 


- Mode of action:   


 


 


 


 Inhibition of TGF-b expression


 


 


 


Inhibition of collagen synthesis (type-I)


 


 


 


  Anti-viral activity:


 


 


 


Anti-inflammatory activity


 


 


 


  Immuno stimulating activity


 






 


Anti-BPH agent


 






 


- Patents resistered in Korea and US


 


 


 


- Patents are pending in UK, France and Gernamy


 


 


 


- Efficacy:


 


 


 


    Anti-inflammatory activity: carrageenin paw-edema test


 


 


 


    Analgesic effect: acetic acid writhing test, tail-flick test


 


 


 


    No lowering effect on blood pressure (in 12 weeks treatment in rats)  in therapeutic dose in man


 


 


 


    Effective in benign prostate hyperplasia (BPH), chronic prostatitis, etc.


 


 


 


- Mode of action:


 


 


 


     Inhibition of a-receptor


 


 


 


     Inhibition of smooth muscle contraction: prostate and urethra specific activity (organ specificity )


 


 


 


     No effects on smooth muscles in stomach and bladder (muscarinic organ)     


 






 


Anti-hypertensive & cholesterol lowering agent


 






 


Patents registered in Korea and US


 


 


 


- Right for Utility model in Germany had been registered


 


 


 


- Efficacy:


 


 


 


    Lowering high blood pressure in SHR (Spontaneous Hypertensive Rat)


 


 


 


    Lowering blood cholesterol


 


 


 


    Lowering blood TG


 


 


 


    Improvement of HDL/LDL Ratio     


 


 


 


   - Mode of action :


 


 


 


     angiotensin converting enzyme inhibitor


 


 


 


     Calcium channel blocker


 






 


Anti-cataract agent


 






 


- Patent is registered in Korea and US.


 


 


 


Efficacy:


 


 


 


   - ex vivo test:  Effects on diabetic cataract (xylose induced cataract) in the organ culture by 50% suppression of the cloudy density.


 


 


 


  -  in vivo test: Inhibition of the cataract formation in diabetic rats. (oral administration for 12 weeks)


 


 


 


Mode of action:


 


 


 


  - Inhibition of aldose reductase (causing the increase in the osmolarity and in the oxicative stress of lens):    IC50 value = 11.3 mg/ml


 


 


 


  - Anti-oxidant activity: chemiluminescent oxidation reaction and better antioxidant effects confirmed as compared with vitamine C


 






 


 


 


 


 


 


 


 


 


Product in the market


 


 


 


 


 






 


Product


 






 


Description


 






 


Anti-acne


 


 


 


cosmetics


 






 


l  Anti-inflammatory and anti-biotic activity in cell & animal model


 


 


 


l  Solutions for symptoms of Acne


 


 


 


l  Inhibition of Propionibacterium acnes


 


 


 


l  Including components for the removal of dead cells in epidermal layer


 


 


 


l  Differentiation of DDS (Day & Night Program) 


 


 


 


l  Natural products in worldwide cosmetics DB


 


 


 


l  Patent filed


 


 


 


l  Safety was confirmed


 






 


Anti-atopic dermatitis


 


 


 


cosmetics


 


 


 


 


 






 


l  used non-steroidal plant extract with outstanding efficacy to control the allergy and prevent the skin dry.


 


 


 


l  stabilizing mast cells and prevent the secretion of histamine from mast cells.


 


 


 


 

FEATURED
Last Updated Jul 2017
Technology Type THERAPEUTIC
Phase of Development REGISTERED / FINISHED PRODUCT
GOVERNMENT INSTITUTE

Opportunity Contact