EG-Decorin (compound name: EGT022), a topical ointment for pressure sore and diabetic foot ulcer, induces rapid repair of damaged capillaries. Thus, it promotes enhanced wound healings. EG-Decorin is majorly composed of human-derived protein ADAM-15 and repairs capillaries via recruiting the pericytes. EG-Decorin may be used with growth factor (GF); steroid may be added without GF to promote its efficacy.
In the molecular aspect, EGT022 is a RGD motif containing recombinant polypeptide from human derived protein ADAM-15. EGT022 has a molecular weight of 6.1- kDa and composed of over 58 amino acids.
EGT022 is an approved therapeutic agent for chronic ischemic disorders such as pressure sore and diabetic foot ulcer.
EG-Decorin induces accelerated wound closure and replacement of granulation tissue in pressure sore model induced normal, diabetic, steroid treated, and old aged mice.
EG-Decorin improves proliferative activities of epidermal cells in rabbit full-thickness ear wound model.
EG-Decorin does not induce skin contraction on the wound lesion during wound healing.
EG-Decorin improves microvascular disorders caused by ischemia-reperfusion cycles.
EG-Decorin promotes stabilization and maturation of impaired vessels in wounded lesions.
Expression system in Pichia pastoris and 250L production and purification process is established.