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Genexol PM
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Breast Cancer, Lung cancer, Pancreatic caner(cytotoxic chemotheraphy)
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Genexol-PM is a polymeric micelle formulated paclitaxel, free of Cremophor EL. Objectives with Genexol-PM are to reduce Cremophor EL-related toxicities and to increase therapeutic efficacy. Polymeric micelles are composed of hundreds of amphiphilic diblock copolymers. Block copolymers include poly-(ethylene glycol) used as nonimmunogenic carriers and biodegradable core-forming poly-(D,L-lactic acid) to solubilize hydrophobic drug. Genexol-PM showed 3-times higher maximum tolerated dose in mice vs. Taxol. Genexol-PM (vs. Taxol) showed 2-3-fold higher levels of paclitaxel in tissues including liver, spleen, kidney, lung, and tumors. In vivo antitumor efficacy of Genexol-PM was significantly higher than Taxol. Based on results from Phase I and II trials in Korea/US, the therapeutic dose recommended is 300mg/m2, much higher than Taxol (175 mg/m2). With favorable results from Phase II studies - Breast/Lung Cancer, Genexol-PM obtained a pre-market approval in Korea in July 2006. A phase IIa pancreatic cancer trial is on-going in US.

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Type of Business Relationship Sought
Registered in Korea, US, Japan, China, Canada, Mexico, Australia and Europe<br />(EP). Europe includes Great Britain, Germany, Spain, France, Italy, Holland, Belgium, Switzerland and Sweden.
FEATURED
Last Updated Aug 2017
Technology Type THERAPEUTIC
Phase of Development REGISTERED / FINISHED PRODUCT
GOVERNMENT INSTITUTE

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