Low Cost, High Efficiency Manufacturing Technology
A variety of techniques have been developed for the manufacturing of chiral intermediates; the classical resolution technique, biotransformation technique, and asymmetric synthesis using chiral catalyst. However technology has created trends where the use of microbial fermentation and classical resolution is gradually decreasing, while biotransformation and asymmetric synthesis utilizing chiral salen catalysts is increasing.
Currently Korean chiral drugs, as well as those offered globally, utilize chiral intermediates with high optical purity acquired through asymmetric synthesis. However this technique involves costly chiral catalysts and chiral compounds with substandard levels of optical purity.