Scrophulariae Radix (Scrophularia buergeriana)
- Selected in the screening of neuroprotective and memory enhancing activity
- Used as anti-inflammation agent traditionally
- KD501 : 70% ethanolic extract of Scrophularia buergeriana root
- Standardized extract containing phenyl propanoids and iridoids, as active ingredients
Memory enhancing activity of acute administration of KD501 on latency time of passive avoidance task in β-amyloid induced memory impairment mice.
The Company obtained tranditional herbal extract from Scrophulariae Radix and confirmed the in vitro neuroprotective effect and in vivo memory enhancing effect of the extract, and then identified the active ingredients of the extract. Elcom named the active ingredients KD501, which is a partially purified extract consisting of cinnamate derivates. Elcom holds patent rights for KD501 and the pharmaceutical use thereof.
The positive effect of KD501 on the performance of scopolamine-treated mice in the working memory trial of the water maze test.