Synthesis of multifunctional nanoparticles (MNP-SiO2(dyes)) for PET/ MR/Optical image
To control the of size of magnetic nanoparticles micro emulsion method was used. We obtained 5 ~ 15 nm sized magnetic nanoparticles and total size including silica and dye above 30 nm. The procedure of synthesis was shown in scheme 2. Magnetic core of CoFe2O4 was synthesized by refluxing ethanol solutions of Co2+and Fe3+ and sodium dodecylbenzene sulfonate in the xylene with NH2NH2. Next, according to Stöber process, the CoFe2O4 nanoparticles coated by polypyrrolidone for solubility in ethanol, tetraethyl orthosilicate (TEOS) and fluorescent organic dye modified by triethoxysilane group are mixed with NH4OH at room temperature.