Active ingredients as anti-inflammatory agents
Anti-Sepsis agents developed by SHAPERON, comprise biological surfactant as active ingredients for intravenous injection.
Biological surfactant used to anti-Sepsis agents, is selected from a group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, dehydrocholic acid, a conjugate compound of these acids with glycine or taurine and pharmaceutically acceptable salts thereof.
Specific experimental results below, are related to CCA(conjuaged cholic acids) including GC(sodium glycocholic acid), TCD(sodium taurchenodeoxycholic acid) and TD(sodium taurodeoxycholic acid) as biological surfactiant,
Characteristics of Biological surfactant as anti-Sepsis agents
As Biological surfactant is theraputic agents targating LPS, it inhibits binding of LPS with cells and NF- κ B activation, one of the most crucial signaling pathways in proinflammatory responses by LPS.