Mechanism of Action/s (MOA):
hEGF initiate signaling cascade by binding to the EGF receptor located in the membrane. hEGF promote the growth of fibroblast which synthesize collagen, resulting in regeneration of skin and reduction of wrinkles. hEGF is registered to INCI and used as a functional ingredient for wrinkle care.
GD-EGF(Trade name) : 53aa(exact copy of hEGF)
GD-EGFplus(Trade name) : 90aa(hEGF 53aa + fusion partner 37aa)
In vitro bioassay data:
In vitro activity and the concentration of GD-EGF and GD-EGFplus were determined by using the commercial ELISA kit(EGF immunoassay kit, invitrogen)