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Novel Cell-Killing Peptide
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Apoptosis is referred to programmed cell death in a multi-cellular organism and plays a physiological role to grow a normal cell, to maintain cell homeostasis, to prevent cancer and other diseases and to protect a living body from viral or bacterial infec...
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MECHANISM OF ACTION
Novel use of MTD domain, a C-terminal region of Noxa protein, Higher cell-killing effects of CKP than TRAIL and Cisplatin , Cell-killing effects of CKP peptide variants , Possibility of cell-kill

The core technology of Korea University is to provide a novel cell-killing peptide (CKP) which is derived from a specific region at the C-terminus of Noxa protein and fusion proteins containing the same. As seen below, CKP peptide of the present invention has strong cell-killing effects much higher than TRAIL or Cisplatin.


* PTD: protein transductin domain; ** CTD: cancer targeting domain


In order to analyze the action mode of CKP peptide of the present invention, several substances that are known to kill cells were adopted to compare the cell-killing effects. Above all, CKP peptide, TRAIL and Cisplatin were treated to HeLa cell lines and observed under time-lapse video capture microscopy in some time-interval (for CKP peptide, 20 seconds; TRAIL, 40 seconds; Cisplatin, 3 minutes) for 1 hour and 40 minutes, 3 hours and 30 minutes, 8 hours and 48 hours respectively.  FIG. 1 depicts HeLa cells serially at each time interval. As a result, it is observed that the cell death caused by TRAIL started at about 1 hour and 30 minutes after treatment and reached the maximum level at about 8 hours. To the contrary, HeLa cell started to die at about 10 minutes after treating CKP peptide and most of HeLa cells have died even at 23 minutes and 20 seconds.

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FEATURED
Last Updated Jun 2016
Technology Type THERAPEUTIC
Phase of Development EARLY STAGE
GOVERNMENT INSTITUTE