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Novel Bioactive Compound (MP203) Derived from Fungal Liquid Fermentation_Mycoplus Co., Ltd
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Novel bioactive compound (MP203) derived from fungal liquid fermentation...
Contact Yong U Kim
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-  Polyketides, 508 M.W derived from fungal liquid fermentation.


-  Superior efficacy against antibiotic resistant-pathogens (MRSA, VRE, CRSA etc.). 


-  Stronger and broader antibiotic activity than the vancomycin.


Other effects: anti-acne, oral diseases and animal-pathogens


-  Stable at broad temperatures.


-  None cytotoxicity


-  Mass production and process technology (fermentation, separation and purification) established.


 


 


1.  Mechanism of actions


-  Seems to inhibit membrane synthesis.


-  Not influenced by vancomycin-resistant genes possessed in VREs.


-  IC50 against cancer cells (RKO, DLD1) : 160 ug/ml


-  IC50 against murine lymphocyte : > 1,000 ug/ml


 


 


 


2.  Chemistry and characterization data


 


-  Single novel compound, Polyketides


-  White powder with MW 508


-  Soluble in DMSO, acetonitrile, methanol etc.


-  Stable at over 60° for many hours.

Type of Business Relationship Sought

FEATURED
Last Updated Jun 2016
Technology Type THERAPEUTIC
Phase of Development EARLY STAGE
GOVERNMENT INSTITUTE