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Novel Bioactive Compound (MP203) Derived from Fungal Liquid Fermentation_Mycoplus Co., Ltd
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Novel bioactive compound (MP203) derived from fungal liquid fermentation...
Contact Yong U Kim
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-  Polyketides, 508 M.W derived from fungal liquid fermentation.

-  Superior efficacy against antibiotic resistant-pathogens (MRSA, VRE, CRSA etc.). 

-  Stronger and broader antibiotic activity than the vancomycin.

Other effects: anti-acne, oral diseases and animal-pathogens

-  Stable at broad temperatures.

-  None cytotoxicity

-  Mass production and process technology (fermentation, separation and purification) established.



1.  Mechanism of actions

-  Seems to inhibit membrane synthesis.

-  Not influenced by vancomycin-resistant genes possessed in VREs.

-  IC50 against cancer cells (RKO, DLD1) : 160 ug/ml

-  IC50 against murine lymphocyte : > 1,000 ug/ml




2.  Chemistry and characterization data


-  Single novel compound, Polyketides

-  White powder with MW 508

-  Soluble in DMSO, acetonitrile, methanol etc.

-  Stable at over 60° for many hours.

Type of Business Relationship Sought

Last Updated Jun 2016
Technology Type THERAPEUTIC
Phase of Development EARLY STAGE