Ph Sensitive Block Copolymer and Polymeric Micelle Using the Same_SungKyunKwan Univ.
Korea Health Industry Development Institute (KHIDI) South Korea flag South Korea
Abstract ID:
Ph Sensitive Block Copolymer and Polymeric Micelle Using the Same
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Controlled biodegradation rate in the body


This technology is characterized in that a pH-sensitive poly (amino acid) compound, for example, a poly(β-amino ester), poly(amido amine) or a copolymer thereof is copolymerized with a hydrophilic polyethylene glycol compound to provide a block copolymer, which is sensitive to pH variations in the body, forms micelle structures at a specific pH range and has a controlled biodegradation rate in the body.


 


Stable micelle structure at a specific pH range


The pH-sensitive micelle maintains a stable micelle structure at a specific pH range, for example, pH 7.2~7.4 (i.e., pH range of normal cells in the body). However, the pH-sensitive micelle structure collapses in a pH of 7.2 or lower as can be found in abnormal cells such as cancer cells. Therefore, the pH-sensitive micelle can be used as carrier for target-directed drug delivery to cancer cells.


 


Use of delivery of genes and drugs


The block copolymer capable of forming the above-described pH-sensitive micelles can deliver a diagnostic substance to abnormal cells, and thus can also be applied to the filed of diagnosis including diagnostic imaging.

Type of Business Relationship Sought

FEATURED
Last Updated Jun 2016
Technology Type MEDICAL DEVICE
Phase of Development EARLY STAGE
GOVERNMENT INSTITUTE

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