The core technology of Dong-Guk University is to provide promising method for the preparation of dermal papilla tissue having hair follicle inducting ability. The method makes it possible to form in vitro a quantity of dermal papilla tissues having hair follicle inducting ability and, accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
Background and unmet needs:
There are various forms of hair loss, including male- or female-type alopecia and alopecia areata. In the past, alopecia was treated typically by various methods of implanting artificial hair into hair follicle root bulbs of the scalp, but such artificial hair implant methods had led to some serious problems, and such methods are now banned. Currently, there are two methods employed to treat alopecia: drug or natural substance therapy, and human hair transplantation. The drug or natural substance therapy may retard the progress of alopecia or prevent future hair loss, but it may accelerate hair loss when the medication is stopped after a prolonged use. On the other hand, alopecia surgery involves taking plugs of natural hair from hair-rich occipital hair growing areas and transplanting them to hair-poor areas. To overcome such problems, many researchers have attempted to revive hair follicles by in vitro culturing of hair follicle cells and implanting them in the treatment area.
Discovery and Achievements:
The researchers have paid attention to the fact that mesenchymal stem cells originating from bone marrow, adipose tissue or umbilical cord have characteristics similar to the cells constituting dermal sheath, and accordingly, have attempted to develop an effective method for in vitro reconstitution of dermal papilla tissues. The dermal papilla tissue prepared by the inventive method can induce the formation of hair follicle through its interaction with a hair follicle lacking or promote hair growth in existing hair follicles when transplanted into dermis of a nude mouse.