SG Cap™ is a molecule-capturing platform for studying molecular interactions, including drug-target pairs and protein-protein relationships.
SG Cap™ immobilizes compounds in their natural conformation without affinity tags or other chemical modification.
SG CapTM sol gel formula assembles into a three-dimensional network of pores that are connected by larger channels. The porous format significantly increases load capacity while interconnecting channels reduce diffusion distances compared to competing two-dimensional systems.
Samples flow through channels and are captured inside pores, where they float freely in their native conformations. Samples within the pores can be studied from all angles, while non-specific material easily washes away, reducing the signal-to-noise ratio.
SG CapTM is a unique immobilization method that exceeds the sensitivity and specificity thresholds of currently available technology.
SG CapTM immobilizes proteins, antibodies, chemicals and other molecules in their natural conformations without covalent modifications. Researchers can make any biochips necessary for research purposes
Multiplex diagnostic test kit
SG CapTM is used for multiplex diagnostic kits that screen blood samples for various diseases simultaneously
Identification of drug targets
SG CapTM can identify cellular targets for drugs. This technique can be used to identify target molecules for your library of known drugs or PD (pharmacodynamic) /PK (pharmacokinetic) – optimized compounds.
3. Market Feasibility
The IVD (In vitro diagnostics) market is about 44 billion USD, with the top ten companies holding 80% of the market share.
Development of technology that meets market needs, along with collaboration with international companies, is required.
4. Technical Advantages
SG Cap™ captures large amounts of chemicals or macromolecules in their natural conformation, in an active orientation, and without the need for affinity-tag modifications.
SG Cap™ can immobilize 100X more protein than competing 2D surfaces. Because molecules are captured instead of bound, many more functional groups and epitopes on the immobilized molecule are biochemically available to capture targets.
These multiples increase the sensitivity and specificity of certain diagnostic assays and greatly improve the study of molecular interactions between drug-target, antigen-antibody and protein-aptamer pairs.
5. Technical Highlighted Summary
High specificity and sensitivity
SG Cap™ maintains the native conformations of embedded antigens or antibodies, increasing their specific activity and enabling 1000x greater sensitivity than that of current diagnostic technologies.
- Various markers for multiple diseases can be spotted in a single well.
- No interference response or cross reaction between spots
Sol-gel and polymer substrate lowers the material cost to one sixth of conventional ELISA kit screening tests.