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Mesp-1 Expression Method to Produce Enriched Cardiovascular Progenitors from Stem Cells
Université Libre de Bruxelles Belgium flag Belgium
Abstract ID:
In the present invention, Mesp1 is identified as the key molecular determinant of multipotent cardiovascular method of differentiation of stem cells into cardiovascular progenitor cells.
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STATE OF THE ART

The heart is composed by different cell types, including contractile cardiac cells, vascular cells, smooth muscle cells as well as pacemaker cells. During embryonic development as well as during embryonic stem cell (ESC) differentiation, the different cardiovascular cell types arise from the differentiation of multipotent cardiovascular progenitors. The mechanism that promotes multipotent cardiovascular

progenitor specification from undifferentiated mesoderm cell remains largely unknown.

THE INVENTION

In the present invention, Mesp1 is identified as the key molecular determinant of multipotent cardiovascular method of differentiation of stem cells into cardiovascular progenitor cells including the steps of:

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References
MAIN PUBLICATIONS (related to the patent)
- Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. Bondue A, Tnnler S, Chiapparo G, Chabab S, Ramialison M, Paulissen C, Beck B, Harvey R, Blanpain C.; J Cell Biol. 2011 Mar 7;192(5):751-65.
- Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Bondue, A., Lapouge, G., Paulissen, C., Semeraro, C., Iacovino, M., Kyba, M. and Blanpain, C. (2008); Cell Stem Cell 3(1):69-84
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Last Updated Sep 2014
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