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Human Cortical Neurons From IPS Cells
Université Libre de Bruxelles Belgium flag Belgium
Abstract ID:
Using induced pluripotent stem (iPS) cells, the team of Pr. Vanderhaeghen developed a simple and efficient method to generate human cortical neurons and in vitro models of human neuronal diseases.\r\nThe quality of the human cortical neurons generated by th
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STATE OF THE ART

Neurobiological diseases affecting the cortex, such as Alzheimer, epilepsy, mental retardation, ADHD and autism, are a burden for society. Yet, drug development is impeded by the lack of animal models recapitulating the clinical features of these diseases.

There is thus a need for models of human neurobiological diseases in support to drug development processes.

THE INVENTION

Using induced pluripotent stem (iPS) cells, the team of Pr. Vanderhaeghen developed a simple and efficient method to generate human cortical neurons and in vitro models of human neuronal diseases.

The quality of the human cortical neurons generated by this technique is demonstrated by their functional grafting into mouse brain.

This method is based on the internationally-renowned scientific work of the Vanderhaeghen laboratory on deciphering key pathways involved in developmental neurobiology.

COMMERCIAL INTEREST

A patented method to produce well-defined and disease-relevant human cortical neurons to use as reagent in support to drug development processes .

KEY ADVANTAGES OF THE Description of Technology

Well-defined identity of the human cortical neurons

High homogeneity of the cell sample

Differentiation into healthy cortical neurons

Differentiation into functional disease-relevant cortical neurons
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Partnership or license agreement
FEATURED
Last Updated Sep 2014
Technology Type
Phase of Development
UNIVERSITY

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