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Université Libre de Bruxelles
Using induced pluripotent stem (iPS) cells, the team of Pr. Vanderhaeghen developed a simple and efficient method to generate human cortical neurons and in vitro models of human neuronal diseases.\r\nThe quality of the human cortical neurons generated by th...
STATE OF THE ART
Neurobiological diseases affecting the cortex, such as Alzheimer, epilepsy, mental retardation, ADHD and autism, are a burden for society. Yet, drug development is impeded by the lack of animal models recapitulating the clinical features of these diseases.
There is thus a need for models of human neurobiological diseases in support to drug development processes.
Using induced pluripotent stem (iPS) cells, the team of Pr. Vanderhaeghen developed a simple and efficient method to generate human cortical neurons and in vitro models of human neuronal diseases.
The quality of the human cortical neurons generated by this technique is demonstrated by their functional grafting into mouse brain.
This method is based on the internationally-renowned scientific work of the Vanderhaeghen laboratory on deciphering key pathways involved in developmental neurobiology.
A patented method to produce well-defined and disease-relevant human cortical neurons to use as reagent in support to drug development processes .
KEY ADVANTAGES OF THE TECHNOLOGY
• Well-defined identity of the human cortical neurons
• High homogeneity of the cell sample
• Differentiation into healthy cortical neurons
• Differentiation into functional disease-relevant cortical neurons
Type of Business Relationship Sought
Partnership or license agreement
Last Updated Sep 2014