Hydroxyapatite (HA) is the main mineral component of bones and teeth. Attempts have been made in the past to create synthetic HA; however high costs and the resulting brittle products have yielded little by way of commercial viability. Scientists at the Biomatcell Vinn Excellence Center of biomaterials and Cell therapy in Sweden have developed novel bioactive surfaces and spheres with controlled morphology and structure which provides a new type of natural HA with strong commercial potential.
The bioactive materials can be provided in two specific ways; firstly coatings (Zion) that are coated to surfaces such as titanium and then implanted into the body. Tests have already shown that coatings improve osseointegration into bones and at a fast rate which is important for patients to make a quick recovery. This process would be useful in the osseointegration of implants such as hips, teeth, etc. There is positive pre clinical data available for the impact of coatings in animals; when tested in rats upon a titanium surface the bioactive materials were shown to enhance osseointegration into bones.
The second structure of the biomaterials are as bioactive spheres (Psilox, particles) which essentially act as ‘fillers' into bone cavities/areas that have disintegrated and need bulking up; by inserting the particles into the area, a quicker build up of natural material has been shown to occur in animal experiments.
By adding bioactive spheres to tooth paste formulations positive properties like bleaching and desensitization can be achieved
In other applications, the biomaterials can be combined with additional pharmaceutical active substances enabling drug delivery to specific sites in the body for action.
This technology therefore could be used in a number of ways such as:
1. Orthopaedic repair/regeneration products
2. Implant anchoring
3. Bone voids/fillers
4. Consumer health products e.g. Incorporated into toothpastes, bleaching pastes
5. Drug delivery systems
Enquiries are naturally welcomed from all companies who are focused within the above areas.