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Biodegradable Triblock Cipolymers, Synthesis Methods Therefor, and Hydrogels and Biomaterials Made
Exploit Technologies Pte Ltd Singapore flag Singapore
Abstract ID:
Our drug delivery system includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer. Copolymers can be formulated to be bioabsorbable, biocompatible, and are capable of forming hydrogel with cyclodextrin....
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Many drugs are compounded for delivery by methods that result in a therapeutic effect in the body of a human that varies considerably over time. Drug dosing may need to be repeated at frequent intervals, such as daily, but this at best only approximates a continuous or constant therapeutic level. Hence, it would be beneficial to deliver many types of therapeutic agents in a delivery system that provides for sustained release of the agents over an extended period of time. A variety of polymers for controlled release and delivery of drugs have been developed in the past 20 years. Most involves complicated fabrication processes or the use of organic solvents which cause denaturation of some protein drugs and even traces of the solvent being toxic. Hence, a new synthesis method should be made less complicated and organic solvents or reagents used should not cause any toxicity or denaturation of protein drugs.


Our Innovation


Our drug delivery system includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer. Copolymers can be formulated to be bioabsorbable, biocompatible, and are capable of forming hydrogel with cyclodextrin. To yield the desired triblock copolymer, the prepolymers are preferably first dried as the coupling reaction is humidity sensitive. The target triblock copolymer is then isolated and purified through one or more precipitations and careful fractionations with mixed solvents. Properties of hydrogels are tunable by using different polymer block molecular weights, be adjusting the cyclodestrin content and through the use of secondary polymers. Drug may suitably be in a macromolecular form or in a low molecular weight form. A couple of therapeutic agents (drugs) can be delivered by these hydrogels.

Type of Business Relationship Sought

Licensing, Co-Development, Start Up Company.

FEATURED
Last Updated Nov 2014
Technology Type
Phase of Development EARLY STAGE
CORPORATION