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Wake Forest Innovations
This treatment uses nanoparticle technology to deliver hyperthermic chemotherapy to patients with metastatic abdominal cancer. This enables intraperitoneal chemotherapy to be delivered using lower doses with higher efficacy, thus limiting toxicity.
Cancers of the abdomen, such as stomach, colorectal, or ovarian cancer, are difficult to treat effectively due to their tendency to metastasize. The current state-of-the-art treatment, intraperitoneal hyperthermic chemotherapy (IPHC), is effective against tumor cells but also causes undesirable side effects in healthy cells. By incorporating nanoparticle-based compositions into the treatment plan, researchers maximize IPHC efficacy while minimizing side effects due to drug interaction with healthy cells.
Researchers at Wake Forest University have developed novel nanoparticle-based compositions that can be used to maximize the effectiveness of IPHC while reducing the toxicity of the chemotherapeutic agent to healthy cells. To maximize effectiveness, anti-cancer drugs are heated and then circulated through the peritoneum. Methods of using this composition have been shown experimentally in vitro to reduce the therapy time by over 200 fold (from 2 hours to a mere 30 seconds).
Reduction in time of drug perfusion from hours to seconds
Requires no attachment of cancer drugs to the nanoparticle
Potential reduction in patient side effects
Reduction in the amount of anti-cancer drug needed, drastically reducing cost
Novel nanoparticle-based compositions promise to maximize the effectiveness of IPHC
This technology could be incorporated into a wide range of other hyperthermic-based chemotherapeutics
Stage of Development
Proof-of-principle studies in vitro demonstrated the ability of nanoparticle-based compositions to reduce therapy time by over 200 fold.
Preclinical animal model completed
Intraperitoneal hyperthermic chemotherapy (IPHC) is a promising therapy for peritoneal dissemination of colorectal and appendiceal cancers. IPHC involves a multi-hour circulation of heated anti-cancer drugs (such as oxaliplatin or mitomycin C) in the peritoneum. Hyperthermia increases cellular metabolism and membrane permeability, resulting in enhanced drug uptake by cells. Although IPHC has significantly improved patient outcomes, the procedure is hampered by the time that the patient must be anesthetized (hours) and the amount of drug perfusate necessary (liters).
Levi-Polyachenko, et al . Rapid Photothermal Intracellular Drug Delivery Using Multiwalled Carbon Nanotubes. Molecular Pharmaceutics 2009 Jul-Aug;6(4):1092-9.
Nanotubes for rapid photothermal intracellular drug delivery. SciBX . July 9, 2009.
Nicole Hope Levi, PhD
Plastic and Reconstructive Surgery
John H. Stewart, IV, MD
David L. Carroll, PhD
Hyperthermic chemotherapy treatment
Nanoparticle Description of Technology
Charlie Shaw, PhD
Wake Forest Innovations
Type of Business Relationship Sought
Exclusive Licensing Arrangement
Possibility of a parallel Sponsored Research Agreement
Last Updated Feb 2014