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A Novel Antibody to Identify Erythroid Precursors in Bone Marrow Biopsy Specimens (Ref # WFU 13-01)
Wake Forest Innovations United States flag United States
Abstract ID:
A novel antibody to Ferritin H that can be used to accurately diagnose erythroid leukemia and will be useful in both clinical diagnostic hematopathology and research labs.
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Value Proposition

Ferritin H is an excellent marker of erythroid precursors in bone marrow specimens. Compared to traditional markers that express at relatively low levels in early erythroid precursors while high levels in mature erythrocytes, Ferritin has the highest expression only in early erythroid precursors, and its expression is negative in mature erythrocytes and other hematopoietic lineages. The Ferritin H antibody is a more reliable diagnostic tool used in immunohistochemistry to identify acute erythroid leukemia (M6), a disease diagnosed by the presence of early erythroid precursors.

Invention Summary

Researchers in the Pathology and Biochemistry departments of Wake Forest School of Medicine have designed a monoclonal antibody to a specific epitope of Ferritin H. The Ferritin H antibody can be applied in immunohistochemistry to stain Ferritin in early erythroid precursors. It is used as a marker of early erythroid precursors to diagnose acute erythroid leukemia (M6) and other diseases associated with erythroid dysplasia.

Competitive Benefits

Type of Business Relationship Sought
Exclusive Licensing Arrangement
Possibility of a parallel Sponsored Research Agreement
Last Updated Feb 2014
Technology Type DIAGNOSTIC
Phase of Development PRECLINICAL

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