A Novel Antibody to Identify Erythroid Precursors in Bone Marrow Biopsy Specimens (Ref # WFU 13-01)

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United States

A novel antibody to Ferritin H that can be used to accurately diagnose erythroid leukemia and will be useful in both clinical diagnostic hematopathology and research labs.

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Value Proposition

Ferritin H is an excellent marker of erythroid precursors in bone marrow specimens. Compared to traditional markers that express at relatively low levels in early erythroid precursors while high levels in mature erythrocytes, Ferritin has the highest expression only in early erythroid precursors, and its expression is negative in mature erythrocytes and other hematopoietic lineages. The Ferritin H antibody is a more reliable diagnostic tool used in immunohistochemistry to identify acute erythroid leukemia (M6), a disease diagnosed by the presence of early erythroid precursors.

Invention Summary

Researchers in the Pathology and Biochemistry departments of Wake Forest School of Medicine have designed a monoclonal antibody to a specific epitope of Ferritin H. The Ferritin H antibody can be applied in immunohistochemistry to stain Ferritin in early erythroid precursors. It is used as a marker of early erythroid precursors to diagnose acute erythroid leukemia (M6) and other diseases associated with erythroid dysplasia.

Competitive Benefits

� Ferritin H is expressed specifically in erythroid precursors, making it is a more reliable marker of early erythroid precursors to diagnose M6

� The Ferritin H antibody is novel, easy to use and has no cross-activity

� The Ferritin H antibody can also be used to stain macrophages for research and diagnostic purposes

Application Fields

� This antibody is used to identify and differentiate early erythroid precursors from other cell types to accurately diagnose M6 and other erythroid precursors involved in hematopathologic disorders.

� This antibody is also useful for identifying macrophages in immunohistochemistry for research and diagnostic purposes.

Stage of Development

� Validated

� Preliminary study using bone marrows with different types of leukemia has been performed. Ferritin H is expressed specifically in erythroid precursors, and the antibody can accurately identify acute erythroid leukemia (M6).

Introduction/Background

� Accurately identifying early erythroid precursors is crucial in acute erythroid leukemia (M6) diagnosis.

� The current erythroid precursor markers are not expressed exclusively in erythroid precursors and are not reliable markers of erythroid precursors.

� For example, the traditional markers of erythroid precursors (glycophorin A and hemoglobin A) have a high level of expression in mature erythrocytes.

� The recently identified erythroid precursors maker CD71 is expressed in other proliferating cells.

Inventors

� Michael Beaty, MD

� Suzy Torti, PhD

� Frank M. Torti, MD

� Wei Wang, PhD, MD

Key Words

� Ferritin H antibody

� Acute erythroid leukemia (M6)

Type of Business Relationship Sought

Exclusive Licensing Arrangement
Possibility of a parallel Sponsored Research Agreement

FEATURED

Last Updated Feb 2014