Invite someone you know to join Pharmalicensing.com
Change Password
PL Stealth Mode
Go Incognito on Pharmalicensing.
All interaction tracking will be disabled, rendering you invisible to other Pharmalicensing users and technology providers.
Stealth Mode currently OFF.
Included with Premium accounts. Add-on upgrade to Plus accounts.
Register
or
Sign in
to Save this opportunity, or Send an Inquiry.
You must be signed in to send an inquiry.
Please Register or Login to save this technology and benefit from all of Pharmalicensing's features.
Select to Save this to or Remove this from an Existing Collection
A Novel Antibody to Identify Erythroid Precursors in Bone Marrow Biopsy Specimens (Ref # WFU 13-01)
Wake Forest InnovationsUnited States
Abstract ID:
A novel antibody to Ferritin H that can be used to accurately diagnose erythroid leukemia and will be useful in both clinical diagnostic hematopathology and research labs.
Send an Inquiry
Value Proposition
Ferritin H is an excellent marker of erythroid precursors in bone marrow specimens. Compared to traditional markers that express at relatively low levels in early erythroid precursors while high levels in mature erythrocytes, Ferritin has the highest expression only in early erythroid precursors, and its expression is negative in mature erythrocytes and other hematopoietic lineages. The Ferritin H antibody is a more reliable diagnostic tool used in immunohistochemistry to identify acute erythroid leukemia (M6), a disease diagnosed by the presence of early erythroid precursors.
Invention Summary
Researchers in the Pathology and Biochemistry departments of Wake Forest School of Medicine have designed a monoclonal antibody to a specific epitope of Ferritin H. The Ferritin H antibody can be applied in immunohistochemistry to stain Ferritin in early erythroid precursors. It is used as a marker of early erythroid precursors to diagnose acute erythroid leukemia (M6) and other diseases associated with erythroid dysplasia.
Competitive Benefits
• Ferritin H is expressed specifically in erythroid precursors, making it is a more reliable marker of early erythroid precursors to diagnose M6
• The Ferritin H antibody is novel, easy to use and has no cross-activity
• The Ferritin H antibody can also be used to stain macrophages for research and diagnostic purposes
Application Fields
• This antibody is used to identify and differentiate early erythroid precursors from other cell types to accurately diagnose M6 and other erythroid precursors involved in hematopathologic disorders.
• This antibody is also useful for identifying macrophages in immunohistochemistry for research and diagnostic purposes.
Stage of Development
• Validated
• Preliminary study using bone marrows with different types of leukemia has been performed. Ferritin H is expressed specifically in erythroid precursors, and the antibody can accurately identify acute erythroid leukemia (M6).
Introduction/Background
• Accurately identifying early erythroid precursors is crucial in acute erythroid leukemia (M6) diagnosis.
• The current erythroid precursor markers are not expressed exclusively in erythroid precursors and are not reliable markers of erythroid precursors.
• For example, the traditional markers of erythroid precursors (glycophorin A and hemoglobin A) have a high level of expression in mature erythrocytes.
• The recently identified erythroid precursors maker CD71 is expressed in other proliferating cells.
Inventors
• Michael Beaty, MD
• Suzy Torti, PhD
• Frank M. Torti, MD
• Wei Wang, PhD, MD
Key Words
• Ferritin H antibody
• Acute erythroid leukemia (M6)
Clinical Trial Information (0)Hide
Type of Business Relationship Sought
Exclusive Licensing Arrangement
Possibility of a parallel Sponsored Research Agreement
FEATURED
Last Updated Feb 2014
DIAGNOSTIC
PRECLINICAL
CORPORATION
Wake Forest Innovations
575 North Patterson Avenue, Suite 550
Winston-Salem , NC 27101
United States