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Synthesising DNA-binding Polyamides
Health Technologies at Strathclyde United Kingdom flag United Kingdom
Abstract ID:
High-yield method for synthesising DNA- binding polyamides...
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Background


DNA-binding polyamides are small molecules that can be designed to target virtually any pre-determined DNA sequence and offer a potentially generic approach for the regulation of gene expression. They have the ability to alter disease states and have affinities and specificities that equal or exceed natural eukaryotic transcriptional regulatory proteins, however, a major barrier to the wider use of polyamides has been the ability to prepare diverse collections of polyamides in high yields, quickly and cost effectively.


Technology


We have developed a new, highly efficient method of synthesising DNA-binding polyamides.


Key Benefits


·         ????????????High yield: increases in yields (up to 180 fold) over current state of the art synthetic methods have been achieved.


·         Cost effective: provides significant cost benefits, including increased capacity for automation and high throughput.


·         Versatile: allows highly modular synthesis of polyamides regardless of monomer type, facilitating the synthesis of more complex polyamides.


Markets and Applications


DNA-binding polyamides have the potential to compete with RNA interference in gene silencing. There is an actively growing research tool market for RNA interference reagents and it is estimated that the global market will be worth $232M by 2012. The relative ease of delivery of polyamides to cells when compared to RNA interference gives polyamides a significant advantage and strengthens their potential to have an impact as therapeutic agents in addition to being versatile, easy to use, research tools.

Type of Business Relationship Sought

Contact is welcomed from organisations interested in developing, or exploiting this technology

FEATURED
Last Updated Oct 2013
Technology Type
Phase of Development EARLY STAGE
UNIVERSITY