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Ultrafast 2D-1R Spectroscopy
Health Technologies at Strathclyde United Kingdom flag United Kingdom
Abstract ID:
Unique biological structural information obtainable using advanced laser methods
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Infrared spectroscopy is a powerful tool but when used in solutions or for complex (bio)molecular systems, vital information is obscured by broad, overlapping lines. Ultrafast 2D-IR spectroscopy provides a solution to this by using advanced laser-methods to generate multidimensional spectra that provide unique structural information. 2D-IR also offers a real-time (100fs) capability to observe short-lived species and dynamic behaviour like hydrogen bond fluctuations.


Ultrafast 2D-IR spectroscopy is the vibrational spectroscopy analogue of 2D-NMR experiments. Based on ultrafast lasers, 2D-IR can probe beneath the ‘normal’ infrared spectrum of a sample, providing direct structural information and real-time dynamics that are unreachable with FTIR and NMR technology. 2D-IR is ideally-suited to observing biological processes such as protein folding, protein-ligand binding and for detecting transient species formed during reactions.

Key Benefits

·         Solution phase measurements allow studies of biomolecules in a close-to-native environment

·         100 fs time resolution allows access to fast process such as Hydrogen-bond dynamics which are crucial to protein structure, protein-drug binding and protein-DNA interactions

·         Small sample volumes mean low quantities of sample are needed

·         Real time measurements of chemical processes allow insights into reaction mechanisms

Markets and Applications

2D-IR spectroscopy is ideally suited to biological and biochemical applications, solution phase chemical systems and thin films.Information most readily available relates to ultrafast dynamic processes in solution such as chemical exchange, transient reaction processes or Hydrogen bond fluctuations.

Type of Business Relationship Sought

This technology can be accessed on a contract or collaborative basis to industrial and academic partners.

Last Updated Oct 2013
Technology Type
Phase of Development EARLY STAGE

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