The current invention refers to the development of a bone scaffold using naturally occurring biomaterials such as alginate and calcium carbonate of nacreous origin. The use of nacreous materials obtained from sea shells in the quest for bone replacement materials are rather cheap and abundantly available worldwide. The aragonite form of calcium carbonate obtained from cockle shell in its nano particle form proves to be an interesting biomineral for bone grafting purposes. An interesting feature of the aragonite mineral form is also regarded to its similarities to the human bone density.
The present invention relates to a nanocomposite bone scaffold and a method for preparing nancomposite bone scaffold. The nanocomposite bone scaffold consists of nanoparticles Calcium Carbonate from Cockle shell, and alginate. Advantageously, the nanocomposite bone scaffold is usable as fracture void fillers to facilitate bone growth in order to shorten healing period.
The developed nano biocomposite bone scaffold provides a cheaper alternative for bone tissue engineering as it is produced using simple methods from naturally sourced materials. The invention solves the need for expensive materials, various chemicals and complicated tedious production methods as used in the development of the bone scaffolds in previous studies. The results of the in-vivo studies showed better quality of bone healing with scarcely remaining scaffold biomaterials comparative to prior studies. Some of the uniqueness of the current invention include; excellent biocompatibility as proved through in-vitro and in-vivo studies; good osteoconductivity in facilitating regeneration of new bones; relatively simple preparation methodology for ease of production and the use of easily available, inexpensive, natural biomaterials that is biologically inert.