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Nozovent - Anti Snoring Spray
Pharmacure Health Care International AB Sweden flag Sweden
Abstract ID:
Nozovent Anti-Snoring Spray helps to dampen snoring. It moisturises the tissue at the back of the palate and the upper part of the pharynx. When the moisture in the mucosa increases, the elasticity of the tissue is improved.
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Nozovent Anti-Snoring Spray is made up of a combination of three natural vegetable oils, olive oil, sunflower oil and peppermint oil, the last of which gives it a refreshing flavour.

It also contains vitamin E and vitamin B6. Vitamin E provides protection from free radicals, which interact with the cells in the body and inflammatory substances such prostaglandins and leukotrienes. The daily vitamin E requirement is 12 mg and Nozovent Anti-Snoring Spray provides about half the normal dose.

Vitamin B6 is needed to form connective tissue, repair damaged cells and reduce the fluid content in the tissues. A normal dose of Nozovent Anti-Snoring Spray provides about 1 mg of vitamin B6 which has the opportunity to exert a local effect. The daily vitamin B6 requirement is 3 mg, most of which is obtained from food (fish, meat and some vegetables).

Nozovent Anti-Snoring Spray is designed to be used by people who suffer from snoring.

When the upper airways are partially constricted, a disruptive noise, snoring, is produced when people inhale during sleep. Between 20 % and 30 % of the population snore. This figure is considerably higher among men after the age of 50. The noise level can correspond to the start of a heavy motorcycle, around 80 decibels.

Snoring can also occur in combination with breathing stoppages (apnea), which can reduce oxygen saturation and increase the level of carbon dioxide in the blood. Individuals who suffer from severe snoring in combination with breathing stoppages should consult a doctor. Less severe forms can be treated with Nozovent Anti-Snoring Spray alone or in combination with Nozovent Classic/Nozovent Nasal Strip.

The palate has for many years been regarded as the main tissue involved in creating the snoring noises. During the years many surgical methods to remove the palate have been invented and tested, some of them giving post operative discomfort for years and in many of those operated the snoring recurs. Implants in the palate have also been used.

Another way to influence the palate is to spray vegetable oils on the pharyngeal mucosa. When this was done on snorers in a previously presented (ref. 4) cross-over, controlled study; the bedroom partners observed that the snoring was significantly decreased. In the present study was observed that the loudness of snoring decreased significantly during the nights vegetable oils were used. The snorers also snored less during the nights when they had tested the vegetable oils, the improvement was, however, not significant.

The snorers themselves rated their own sleep as highly significantly better the nights they used the vegetable oils. One might argue that the results depends on that no placebo was tested. Against this can be said that it is possible that any vegetable oil may have a similar effect on snoring, but the oils then have to be tested to prove it. We have only shown that the presented and used oils have a good effect.

As another good effect of the used vegetable oils is to mention that the snorers well-being in the morning was significantly better, the snorers felt more thoroughly rested and they also had significantly less mouth dryness. To verify whether the vegetable oils had any effect on the sleep the snorers had to use a somnograph on both the night when the vegetable oils was used and when it was not. To avoid the so-called first night effect (ref. 5) half of the snorers had the first night with vegetable oils and the other half of the snorers started without vegetable oil. A random numbers table was used to select the order although it has been shown that there was no statistical difference of poly-somnographic values between two consecutive nights in a hospital sleep laboratory (ref. 5).

When the snorers were recruited it was the intention to avoid test subjects with obstructive sleep apnea. Depending on the limits for AHI we partly succeeded, no one had an AHI above 15 but 3 had AHI between 10 and 15, and 7 had AHI between 5 and 10. This shows how difficult it is to be sure that you recruit test subjects without obstructive sleep apnoea. On the other hand we see no reason to exclude these test subjects as they have fulfilled the study which intension was to test a new way of treating snoring. The purpose was not to select and exclude any test subject that had problems with snoring and not were aware they had apneas.

The tested vegetable oils had a positive effect on AHI, there was a decrease in the mean value from 4.7 to 3.4, an improvement that was not significant. Neither was there any significant improvement in average oxygen saturation.

Regarding oxygen desaturation index there was a significant improvement from 4.7 to 2.7 when the vegetable oils were used. This shows that the condition of the palate and the mucosa of the pharynx are of importance when it comes to the loudness of the snoring sounds, as shown before, but also when it comes to oxygenation during sleep which might be of more importance to the snorer than the sounds that are generated.

This study shows positive effects of certain vegetable oils given in the relatively large dose of 2 ml to the upper side of the pharynx. It is very simple to use. The vegetable oils in the tested medical device are commonly used for food preparation, the vitamins added to the oils are also found in food that most people eat. The only ingredient that is not found generally in food is peppermint; on the other hand it is frequently used in dental paste or sweets.

Last Updated May 2016
Technology Type THERAPEUTIC
Phase of Development CLINICAL TRIALS

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