Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/detail.php on line 234

Warning: in_array() expects parameter 2 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 82

Warning: array_push() expects parameter 1 to be array, null given in /home/pharmalicensing/public_html/inc_stats.php on line 85
Pharmalicensing | Life Science's Global Technology Marketplace
Save this technology
close
Save to Existing Project
Save to a New Project
IGF Trap for Tumor Growth and Metastasis
AmorChem Canada flag Canada
Abstract ID:
An IGF Trap is being developed to target IGF-1 levels that has shown efficacy in breast, colon and lung cancer....
Contact John Clement
Participants
You
Email me a copy of this message

Breast cancer remains the most commonly diagnosed cancer, of which as much as 15% of cases are referred to as triple-negative breast cancer (TNBC), which refers to those tumors which are negative for ER, PR and Her2 and it is an unmet medical need. The IGF-1 growth factor and its receptor (IGF-1R) is an axis that is validated as a cancer target, and to date almost a dozen IGF-1 targeting candidates have reached clinical testing. These include mAbs against the IGF-1R, mAbs targeting the human ligands IGF1/2, and inhibitors of the IGF-1R associated tyrosine kinases (TKs). Thus far, no approach has proven efficacious, primarily due to cross-talk and impact on insulin signaling pathways.

The technology in this opportunity, referred to as the “IGF-1R Trap”, is a decoy receptor for IGF growth factors and it has produced some remarkable results in preliminary animal modeling of various cancers.

GO PREMIUM TO GET PATENT INFORMATION
Type of Business Relationship Sought
Out-licensing or collaboration
FEATURED
Last Updated Aug 2016
Technology Type THERAPEUTIC
Phase of Development PRECLINICAL
CORPORATION